Diagnosis for facial disharmony, jaw discrepancy, tooth mal-alignment can be assessed as early as age 6, as the permanent tooth erupts. 

Early loss or retained milk tooth can lead to shift and change in the eruption of underlying permanent tooth. 

Use of space maintainers may help not only prevention of space loss but also guides the eruption of permanent tooth normal occlusion. 

Small jaw versus Big teeth and vice versa, space discrepancy, prevention of removal of permanent teeth during braces treatment by age 12 can be addressed by use of Myo-functional appliance and growth modifiers.